1. The dentate nucleus is not affected until late in disease progression. 2. Abnormalities are seen in the basal ganglia and dentate nucleus . 3. Similar abnormalities have been identified in the brainstem and cerebellar dentate nucleus . 4. The dentate nucleus is mostly responsible for planning and execution of fine movement. 5. Dentate nucleus axons can be divergent or convergent.6. The dentate nucleus is responsible for the planning, initiation and control of voluntary movements. 7. The dentate nucleus sends commands and information to the motor and premotor areas in the forebrain. 8. Morphological changes in the dentate nucleus may contribute to the pathological substrate of myoclonus in AD. 9. Bilaterally symmetric defects are seen in the periaqueductal grey matter, brain stem, basal ganglia, and dentate nucleus . 10. Three modalities are received by cerebellum, including proprioception, nociception, and somatic input, and all of these stimulate the dentate nucleus .
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